Josh Adams will make his Wales debut against Scotland when the NatWest 6 Nations gets underway at the Principality Stadium on Saturday (kick-off 2.15pm).
The 22-year-old, who has been in sensational form for Warriors this season, will pull on the Wales jersey on one of the biggest stages of world rugby.
Adams has raced to the top of the Aviva Premiership tryscoring charts this season after racking up nine league tries this season and was rewarded with a Wales call-up earlier this month.
He will become the first Warrior to play for Wales since Chris Horsman over a decade ago.
Wales Head Coach Warren Gatland said: “The first-up game against Scotland this weekend is really important for us and this is a great chance for this group of players to get us off to a good start.
“We have been watching Josh (Adams) closely. He is top try-scorer in the English Premiership and has been going well and we are excited for him.
“For this opening game, we looked at a lot of combinations, especially the front-row. It is exciting to see Samson back playing well and the familiarity of the Scarlets front-row will be important.”
15 Leigh Halfpenny (Scarlets) (74 Caps)
14 Josh Adams (Worcester) (*uncapped)
13 Scott Williams (Scarlets) (51 Caps)
12 Hadleigh Parkes (Scarlets) (1 Cap)
11 Steff Evans (Scarlets) (5 Caps)
10 Rhys Patchell (Scarlets) (5 Caps)
9 Gareth Davies (Scarlets) (27 Caps)
1 Rob Evans (Scarlets) (20 Caps)
2 Ken Owens (Scarlets) (52 Caps)
3 Samson Lee (Scarlets) (34 Caps)
4 Cory Hill (Dragons) (10 Caps)
5 Alun Wyn Jones (Ospreys) (113 Caps) (C)
6 Aaron Shingler (Scarlets) (13 Caps)
7 Josh Navidi (Cardiff Blues) (7 Caps)
8 Ross Moriarty (Gloucester) (17 Caps)
16 Elliot Dee (Dragons) (2 Caps)
17 Wyn Jones (Scarlets) (5 Caps)
18 Tomas Francis (Exeter Chiefs) (26 Caps)
19 Bradley Davies (Ospreys) (57 Caps)
20 Justin Tipuric (Ospreys) (52 Caps)
21 Aled Davies (Scarlets) (5 Caps)
22 Gareth Anscombe (Cardiff Blues) (11 Caps)
23 Owen Watkin (Ospreys) (2 Caps)