Valkyries pair Lydia Thompson and Lark Davies will start for England Women against USA in their opening Quilter International at Allianz Park on Friday (kick-off 7.30pm).
Wing Davies will win her 39th England cap and hooker Davies, the Valkyries captain, her 11th cap on only her second international start.
Fly Katy Daley-Mclean will earn her 100th international cap in a side that includes four newcomers in the starting XV with two more on the bench.
Saracens prop Ellena Perry starts at loosehead with Firwood Waterloo teenager Sarah Beckett at No.8 and in the backs, centres Tatyana Heard (Gloucester-Hartpury) and Carys Williams (Loughborough Lightning) start at 12 and 13 respectively.
With regular Red Roses captain Sarah Hunter on the bench for this opening game, Harlequins lock Abbie Scott has been named to lead the side. Additionally from the bench, Wasps scrum-half Claudia Macdonald and Bristol Bears centre Lucy Attwood will be looking for their first international appearance.
England Head Coach Simon Middleton said: “We know where we are and there’s a lot of excitement among the squad to start a new international season. We have new talent among the group who have developed their rugby through the pathway and Tyrrells Premier 15s and bring a mix of rugby backgrounds to the set up. It’s important to give players opportunities and there is a lot to play for.
“The USA are match-ready from their game against the Black Ferns and will be hardened and wiser for last weekend. Like them, we are ready and expect a tough game on Friday.”
USA Women arrive in the UK having played the Black Ferns on Sunday, losing their first game since the 2017 Women’s Rugby World Cup semi-finals. They most recently played the Red Roses in Ireland last summer, with England coming out 47-26 winners in the opening pools.
England Women
15 Sarah McKenna (Saracens)
14 Lydia Thompson (Worcester Valkyries)
13 Carys Williams (Loughborough Lightning)
12 Tatyana Heard (Gloucester-Hartpury)
11 Kelly Smith (Gloucester-Hartpury)
10 Katy Daley-Mclean (Loughborough Lightning)
9 Leanne Riley (Harlequins)
1 Ellena Perry (Saracens)
2 Lark Davies (Worcester Valkyries)
3 Shaunagh Brown (Harlequins)
4 Zoe Aldcroft (Gloucester-Hartpury)
5 Abbie Scott (Harlequins) (C)
6 Joanna Brown (Loughborough Lightning)
7 Vicky Fleetwood (Saracens)
8 Sarah Beckett (Firwood Waterloo)
Replacements
16 Heather Kerr (Darlington Mowden Park Sharks)
17 Vickii Cornborough (Harlequins)
18 Hannah Botterman (Saracens)
19 Catherine O’Donnell (Loughborough Lightning)
20 Sarah Hunter (Loughborough Lightning)
21 Claudia Macdonald (Wasps FC Ladies)
22 Zoe Harrison (Saracens)
23 Lucy Attwood (Bristol Bears)