Warriors back-row forward Marco Mama will captain the side on his 50th appearance for the club in Saturday’s Gallagher Premiership match against Sale Sharks at Sixways (kick-off 3.00pm).
The 28 year-old Zimbabwean initially joined Warriors on loan from Bristol in 2015 and signed a permanent deal at Sixways in January 2016.
Mama will become the second Warriors player in as many weeks to reach the 50 appearance milestone, following scrum-half Francois Hougaard, and he will move across the back row from number eight to the blindside flank.
Mama will also captain Warriors in the absence of centre Ryan Mills (shoulder ) who had been leading the side while club captain GJ van Velze is sidelined by a broken forearm.
Scotland number eight Cornell du Preez comes into the side at number eight for his first start for Warriors since his move from Edinburgh last summer.
Du Preez suffered a fractured larynx on his debut against Wasps in September and made his comeback as a replacement in the European Challenge Cup quarter-final against Harlequins two weeks ago.
Tighthead prop Nick Schonert has recovered from the back injury that ruled him out of last week’s match at Wasps and he takes his place in a re-jigged front row with Ethan Waller starting at loosehead.
Wing Bryce Heem also returns to the side after recovering from a sore foot and former South Africa international Francois Venter will form a new centre partnership with England’s Ben Te’o in Milss’ absence.
Hooker Jack Singleton returns to the matchday squad as a replacement having recovered from an elbow injury and fly-half Jono Lance is also named on the bench having recovered from the head injury he sustained in the win at Bristol.
Warriors
15 Chris Pennell
14 Bryce Heem
13 Francois Venter
12 Ben Te’o
11 Josh Adams
10 Duncan Weir
9 Francois Hougaard
1 Ethan Waller
2 Niall Annett
3 Nick Schonert
4 Anton Bresler
5 Darren Barry
6 Marco Mama (C)
7 Sam Lewis
8 Cornell du Preez
Replacements
16 Jack Singleton
17 Callum Black
18 Gareth Milasinovich
19 Andrew Kitchener
20 Ted Hill
21 Michael Heaney
22 Jono Lance
23 Tom Howe
Sale Sharks | 15 Luke James, 14 Denny Solomona, 13 Sam James, 12 Rohan Janse van Rensburg, 11 Arron Reed, 10 AJ MacGinty, 9 Faf de Klerk, 1 Ross Harrison, 2 Rob Webber, 3 WillGriff John, 4 Josh Beaumont, 5 James Phillips, 6 Jono Ross (C), 7 Ben Curry, 8 Josh Strauss.
Replacements | 16 Curtis Langdon, 17 Valery Morozov, 18 Joe Jones, 19 Matt Postlethwaite, 20 Sam Moore, 21 Will Cliff, 22 Cameron Redpath, 23 Paolo Odogwu