Warriors will unleash the Sixways young guns against London Irish in the EDF Energy Cup clash at the Madejski Stadium on Sunday (kick-off 3pm).
Exciting young fly half Joe Carlisle is rewarded for his eye-catching form for Warriors in the Guinness A League this season with a start and he is joined by wing speedster Miles Benjamin.
New Zealand international lock Greg Rawlinson is handed a full debut for Warriors and is joined by Will Bowley in the second row.
A changed front row allows Matt Mullan to make his first start of the campaign and he will play alongside Darren Morris, who switches from loosehead to tighthead, and Chris Fortey at hooker.
James Collins is handed a position at flanker and with Netani Talei moving from No.8 there is also a starting jersey for Kai Horstmann.
Summer signing Shaun Ruwers is named on the replacements bench and could make his first team debut. Tony Windo and young scrum half Jonny Arr are also named on the bench.
Warriors v London Irish
15 Chris Pennell
14 Miles Benjamin
13 Mark Tucker
12 Dominic Feaunati
11 Marcel Garvey
10 Joe Carlisle
9 Matt Powell (c)
1 Matt Mullan
2 Chris Fortey
3 Darren Morris
4 Greg Rawlinson
5 Will Bowley
6 Netani Talei
7 James Collins
8 Kai Horstmann
16 Tony Windo
17 Shaun Ruwers
18 Phil Murphy
19 Craig Everett
20 Jonny Arr
21 Shane Drahm
22 Uche Oduoza