Worcester back row Leonardo Senatore will start for Argentina in the opening match of the Rugby Championship against South Africa at Soccer City Stadium this Saturday.
Senatore is named at Number Eight, with Juan Martin Fernandez Lobbe missing with a calf injury, while fellow Warriors new boy and hooker Agustin Creevy is among the replacements.
Senatore is one of eight changes from the team beaten 27-6 by the Springboks in Cape Town at the same stage last year. Senatore and flankers Pablo Matera and Juan Manuel Leguizamon form a fresh back row in place of Lobbe, Alvaro Galindo and Julio Farias Cabello.
The Rugby Championship was expanded last season to include Argentina, which proved competitive apart from a 54-15 home defeat from world champions, New Zealand.
Los Pumas prepared for Soweto by defeating the visiting New South Wales Barbarians 29-27 and 58-12 in a two-match series.
Argentina:Juan Martin Hernandez; Gonzalo Camacho, Marcelo Bosch, Felipe Contepomi (captain), Juan Imhoff; Nicolas Sanchez, Martin Landajo; Leonardo Senatore, Juan Martin Leguizamon, Pablo Matera; Patricio Albacete, Manuel Carizza; Matias Diaz, Eusebio Guinazu, Juan Figallo
Replacements: Agustin Creevy, Nahuel Lobo, Juan Pablo Orlandi, Mariano Galarza, Julio Farias Cabello, Tomas Cubelli, Santiago Fernandez, Horacio Agulla