Euan Murray will start for Scotland against Japan at Murrayfield on Saturday in the first viagogo Autumn Test.
The tighthead prop, who has made six appearances for Warriors this season, will start alongside Ryan Grant and Ross Ford in the front row.
Kelly Brown will captain the side after recovering from the leg injury which cut short his involvement in Scotland’s summer tour to South Africa.
Brown is one of six changes in personnel and two further positional switches from Scotland’s last match – the last-gasp 30-29 victory over Italy in the quadrangular tournament in Pretoria in June.
The modifications see Sean Maitland, Nick De Luca, Ruaridh Jackson, Ryan Grant and Ross Ford join Brown in the starting line-up with David Denton and Alasdair Strokosch listed in their more customary back-row berths.
Scotland head coach Scott Johnson said: “We are looking to the future and we’re also looking at people’s futures too.
“This selection is a first chance for some to put their hand up. We have a 22-month campaign pre-World Cup and one of the mantras is 'this could be your last Test match.'”
Scotland
15 Sean Maitland (Glasgow Warriors) 5 caps, 1 try, 5 points
14 Tommy Seymour (Glasgow Warriors) 2 caps
13 Nick De Luca (Edinburgh Rugby) 38 caps, 1 try, 5 points
12 Matt Scott (Edinburgh Rugby) 15 caps, 3 tries, 15 points
11 Sean Lamont (Glasgow Warriors) 79 caps, 11 tries, 55 points
10 Ruaridh Jackson (Glasgow Warriors) 21 caps, 3 conversions, 2 penalties, 2 drop-goals, 18 points
9 Greig Laidlaw (Edinburgh Rugby) 21 caps, 2 tries, 21 conversions, 47 penalties, 193 points
1 Ryan Grant (Glasgow Warriors), 10 caps
2 Ross Ford (Edinburgh Rugby) 68 caps, 2 tries, 10 points
3 Euan Murray (Worcester Warriors) 56 caps, 2 tries, 10 points
4 Tim Swinson (Glasgow Warriors) 2 caps
5 Alastair Kellock (Glasgow Warriors) 55 caps, 1 try, 5 points
6 Alasdair Strokosch (Perpignan) 35 caps, 2 tries, 10 points
7 Kelly Brown (Saracens) 58 caps, 4 tries, 20 points CAPTAIN
8 David Denton (Edinburgh Rugby) 14 caps
Replacements
16 Pat MacArthur (Glasgow Warriors) 1 cap
17 Alasdair Dickinson (Edinburgh Rugby) 27 caps, 1 try, 5 points
18 Geoff Cross (Edinburgh Rugby) 22 caps, 1 try, 5 points
19 Richie Gray (Castres) 31 caps, 1 try, 5 points
20 John Barclay (Scarlets) 41 caps, 2 tries, 10 points
21 Henry Pyrgos (Glasgow Warriors) 9 caps, 1 try, 5 points
22 Duncan Weir (Glasgow Warriors) 5 caps, 1 conversion, 2 points
23 Duncan Taylor (Saracens) 3 caps