Ben Te’o has been named on the bench for England ahead of their RBS 6 Nations clash against Scotland at Twickenham on Saturday (kick-off 4.00pm, ITV).
The Warriors centre has played a starring role in England's campaign so far, scoring tries against France and Italy.
England have made three changes to the starting line-up which defeated Italy in the third round of the championship to maintain their unbeaten start.
In the back line Jonathan Joseph (Bath Rugby) is reinstated at outside centre, Jack Nowell (Exeter Chiefs) is named on the right wing and Ben Youngs (Leicester Tigers) starts at scrum-half.
Anthony Watson (Bath Rugby) and Billy Vunipola (Saracens) return to an England matchday 23 for the first time in this year’s championship, having both returned from injury.
“Our preparation for Scotland has been very good,” said England Head Coach Eddie Jones. “We had two excellent training runs in Oxford last week and followed that up this week.
“We’re focused on ourselves. We want to give our fans a really good performance. We’ve worked hard in this RBS 6 Nations and feel like a good performance is just around the corner.
“This is the 124th Calcutta Cup and I feel humbled and honoured to be part of such an historic rugby occasion – it’s the oldest international fixture and means a lot to both countries. We treasure the experience.
“I congratulate Joe Marler on his 50-cap milestone. I’ve coached a lot of good players and he is certainly one of the best.
“He is an honest and committed team man and a fine individual. To have him and Mako Vunipola available together to give us 80 minutes at loosehead is an enormous advantage.”
England
15 Mike Brown (vice captain, Harlequins, 58 caps)
14 Jack Nowell (Exeter Chiefs, 21 caps)
13 Jonathan Joseph (Bath Rugby, 31 caps)
12 Owen Farrell (vice captain, Saracens, 50 caps)
11 Elliot Daly (Wasps, 11 caps)
10 George Ford (Bath Rugby, 33 caps)
9 Ben Youngs (Leicester Tigers, 68 caps)
1 Joe Marler (Harlequins, 49 caps)
2 Dylan Hartley (captain, Northampton Saints, 82 caps)
3 Dan Cole (Leicester Tigers, 72 caps)
4 Joe Launchbury (Wasps, 40 caps)
5 Courtney Lawes (Northampton Saints, 56 caps)
6 Maro Itoje (Saracens, 10 caps)
7 James Haskell (Wasps, 73 caps)
8 Nathan Hughes (Wasps, 6 caps)
Replacements
16 Jamie George (Saracens, 15 caps)
17 Mako Vunipola (Saracens, 40 caps)
18 Kyle Sinckler (Harlequins, 6 caps)
19 Tom Wood (Northampton Saints, 48 caps)
20 Billy Vunipola (vice captain, Saracens 32 caps)
21 Danny Care (Harlequins, 69 caps)
22 Ben Te’o (Worcester Warriors, 6 caps)
23 Anthony Watson (Bath Rugby, 24 caps)