Jack Singleton, Ben Te’o, Francois Hougaard and Alafoti Faosiliva are all set for international action in a busy weekend of rugby.
Singleton is named on the bench for England, who take on Argentina, as the young Warrior looks to pick up his first international cap in Santa Fe (kick-off 8.15pm BST, live on BBC2).
Hougaard is named on the bench for South Africa against France as they look to go 2-0 up and win the series at Growthpoint Park Kings Park in Durban on Saturday (kick-off 4pm BST).
Ben Te'o starts for the British & Irish Lions against the Maori All Blacks on Saturday (kick-off 8.35am BST) and Alafoti Faosiliva is also on the bench for Samoa who face a tough test against New Zealand on Friday morning (kick-off 9am BST).
Meanwhile Valkyries duo Lydia Thompson and Rochelle Clark will both start for England Women as they face New Zealand on Saturday in their final Test of the International Women's Rugby Series (kick-off 5.15am BST).