The pair haven’t featured for Warriors in pre-season but are straight into the side which is led by new Club captain Donncha O’Callaghan.
Schonert starts in the front row with Ryan Bower and Jack Singleton while Spencer accompanies O’Callaghan in the second row.
Number eight GJ van Velze returns to the side for his first competitive game in what is almost a year to the day since his last appearance, after returning from a concussion setback.
Vice-captain Van Velze is joined in the back row by Welshman Sam Lewis and Matt Cox while Jonny Arr and Tom Heathcote form the half-back combination.
Jackson Willison and Wynand Olivier form an experienced centre partnership while Josh Adams, Bryce Heem and Dean Hammond occupy the back three.
New signings Ethan Waller, Pierce Phillips, Peter Stringer and Sam Olver are all named on the bench and could make their debuts should they feature in the North.
England and British & Irish Lions star Ben Te’o is also among the replacements.
Warriors
15 Josh Adams
14 Dean Hammond
13 Wynand Olivier
12 Jackson Willison
11 Bryce Heem
10 Tom Heathcote
9 Jonny Arr
1 Ryan Bower
2 Jack Singleton
3 Nick Schonert
4 Donncha O’Callaghan (C)
5 Will Spencer
6 Matt Cox
7 Sam Lewis
8 GJ van Velze
Replacements
16 Joe Taufete’e
17 Ethan Waller
18 Biyi Alo
19 Pierce Phillips
20 Alafoti Faosiliva
21 Peter Stringer
22 Sam Olver
23 Ben Te’o