Josh Adams will start for Wales when they take on Argentina in Santa Fe on Saturday (kick-off 8.40pm BST, live on Channel 4).
Adams will win his fourth cap and make his second consecutive start on the wing as Wales look to end their summer tour with a win.
Wales defeated South Africa 22-20 in their opening match of the tour, before Adams helped his country defeat Argentina 23-10 last weekend.
Wales Head Coach Warren Gatland said: “We’ve made five changes to the starting line-up as we want to see a few players from the start and give those players a bit more opportunity.
“Looking at the objectives of this tour, we are right on track. We have won two games from two but more importantly we have exposed players to Test match rugby and given more opportunity and that was the aim coming in.
“We want to go home three from three but we know the challenge that we are up against this weekend and we also are looking at the bigger picture.
“We might have picked a slightly different team if it was just about results but it is about more than that it is about building for 2019 and we are on the right track.”
Wales
15 Hallam Amos (17 Caps)
14 Josh Adams (3 Caps)
13 Scott Williams (56 Caps)
12 Owen Watkin (5 Caps)
11 George North (75 Caps)
10 Rhys Patchell (9 Caps)
9 Aled Davies (10 Caps)
1 Rob Evans (26 Caps)
2 Ryan Elias (4 Caps)
3 Tomas Francis (32 Caps)
4 Adam Beard (3 Caps)
5 Cory Hill C (17 Caps)
6 Ellis Jenkins (7 Caps)
7 James Davies (2 Caps)
8 Ross Moriarty (23 Caps)
Replacements
16 Elliot Dee (9 Caps)
17 Nicky Smith (20 Caps)
18 Dillon Lewis (4 Caps)
19 Bradley Davies (62 Caps)
20 Josh Turnbull (9 Caps)
21 Tomos Williams (1 Cap)
22 Gareth Anscombe (17 Caps)
23 Tom Prydie (6 Caps)